abstract：:We investigated the ocular fundus of (NZWXBXSB) F1 mice, which are considered to be a good model for systemic lupus erythematosus (SLE) with antiphospholipid syndrome. The abnormal fundus findings were documented by fundus photography, and the chorioretinal lesions were studied histopathologically. The incidence of oc...

journal_title：Japanese journal of ophthalmology

authors： Nakamura A,Yokoyama T,Kodera S,Zhang D,Hirose S,Shirai T,Kanai A

更新日期：1998-09-01 00:00:00

abstract：:A 76-year-old Japanese woman had suffered from fatigue, weight loss, and cutaneous hyperpigmentation at the age of 38 years and was diagnosed as having tuberculous Addison's disease. Since then, corticosteroids had been administered effectively as hormonal replacement. At the age of 75 years, the patient presented wit...

journal_title：Japanese journal of ophthalmology

authors： Kakiuchi T,Uehara F,Ohba N

更新日期：1998-09-01 00:00:00

abstract：:Lacquer cracks are thought to represent healed mechanical breaks in the retinal pigment epithelium, Bruch's membrane, and choriocapillaris complex. In this study, we analyzed the indocyanine green (ICG) angiographic features of lacquer cracks and compared them with findings using fluorescein angiography. Complete opht...

journal_title：Japanese journal of ophthalmology

authors： Ohno-Matsui K,Morishima N,Ito M,Tokoro T

更新日期：1998-07-01 00:00:00

abstract：:Using polymerase chain reaction, we detected the varicella-zoster virus genome in the vitreous humor of two patients with clinically diagnosed acute retinal necrosis. One of the two cases was thought to be caused by infection with a varicella-zoster virus lacking a PstI cleavage site. We could not find any clinical di...

journal_title：Japanese journal of ophthalmology

authors： Mochizuki K,Matsushita H,Hiramatsu Y,Yanagida K

更新日期：1998-05-01 00:00:00

abstract：:Latanoprost (PhXA41, Xalatan) and isopropyl unoprostone (UF-021, unoprostone, Rescula) two new prostanoid derivatives, have been shown to reduce intraocular pressure (IOP) significantly in patients with glaucoma or ocular hypertension. This study was designed to compare the ocular hypotensive effects of latanoprost an...

journal_title：Japanese journal of ophthalmology

authors： Serle JB,Podos SM,Kitazawa Y,Wang RF

更新日期：1998-03-01 00:00:00

abstract：:Regulation of fluid flow through corneal stroma was investigated in the bullfrog. Corneal specimens were mounted by clamping their limbal sclera between the two chambers of a Ussing-type chamber. The epithelial surface was covered with Ringer's solution, while the endothelial surface was superfused with Ringer's solut...

journal_title：Japanese journal of ophthalmology

authors： Kubota S,Kani K,Kitasato H

更新日期：1998-01-01 00:00:00

abstract：:We evaluated postoperative binocularity in a retrospective study of 111 adult strabismus patients in order to identify the factors which influence the success of surgery for horizontal concomitant strabismus in adults. Selection criteria included minimum age of 15 years at time of surgery, and preoperative fusion impa...

journal_title：Japanese journal of ophthalmology

authors： Umazume F,Ohtsuki H,Hasebe S

更新日期：1997-11-01 00:00:00

abstract：:We explored the involvement of CD44 isoforms in lymphoproliferative disorder (LPD) of the lacrimal gland of a Sjögren's syndrome patient with unilateral LPD. The CD44 variant with the v6 exon was selectively detected from infiltrating lymphocytes in the gland with LPD, but not from infiltrating lymphocytes in the norm...

journal_title：Japanese journal of ophthalmology

authors： Hiraoka M,Saito I,Tsubota K,Sugai S,Miyasaka N

更新日期：1997-09-01 00:00:00

abstract：:We evaluated the effectiveness of performing a core vitrectomy to prevent intraoperative posterior chamber pressure evaluation in eyes at high risk for development of this complication, prior to penetrating keratoplasty, extracapsular cataract extraction and posterior chamber lens (IOL) implantation. Results in 10 cas...

journal_title：Japanese journal of ophthalmology

authors： Shimomura Y,Hosotani H,Kiritoshi A,Watanabe H,Tano Y

更新日期：1997-07-01 00:00:00

abstract：:We assessed the function of Endothelin-1 (ET-1) in the development of anterior chamber inflammation in pigmented rabbit eyes. After the injection of ET-1 solution (10(-13), 10(-11), 10(-9), or 10(-7) M, diluted with 300 microL of artificial aqueous humor) into the anterior chamber, the aqueous protein concentration (A...

journal_title：Japanese journal of ophthalmology

authors： Shoji N,Oshika T,Masuda K

更新日期：1997-05-01 00:00:00

abstract：:Hematoxylin-eosin staining, the TUNEL method for in situ detection of the intranuclear DNA fragmentation, which indicates apoptosis, and electron microscopy were used to study the morphologic changes in specimens from the eyes of 8 patients with secondary glaucoma and 2 normal control eyes to evaluate our hypothesis t...

journal_title：Japanese journal of ophthalmology

authors： Okisaka S,Murakami A,Mizukawa A,Ito J

更新日期：1997-03-01 00:00:00

abstract：:A nationwide, multicenter study of typical retinitis pigmentosa (RP) was carried out in collaboration with 18 hospitals throughout Japan to obtain current information for genetic counseling. We analyzed the genetic heterogeneity of RP based on the parental consanguinity of 434 probands registered during a 6-month peri...

journal_title：Japanese journal of ophthalmology

authors： Hayakawa M,Fujiki K,Kanai A,Matsumura M,Honda Y,Sakaue H,Tamai M,Sakuma T,Tokoro T,Yura T,Kubota N,Kawano S,Matsui M,Yuzawa M,Oguchi Y,Akeo K,Adachi E,Kimura T,Miyake Y,Horiguchi M,Wakabayashi K,Ishizaka N,Koi

更新日期：1997-01-01 00:00:00

abstract：:The aqueous humor during or after cataract surgery often contains red blood cells (RBCs) from blood; inflammatory cells from white blood cells (WBCs); fibrin, pigment cells, and fibroblasts from either the iris or the ciliary body; lens epithelial cells (LECs); and corneal endothelial cells. Since LECs may be related ...

journal_title：Japanese journal of ophthalmology

authors： Majima K

更新日期：1997-01-01 00:00:00

abstract：:Experimental melanin-protein induced uveitis (EMIU) is a CD4 T cell-mediated disease involving the choroid and iris, but sparing the retina. The present study was designed to solubilize uveitogenic antigen from melanin granules without enzymatic digestion, and to investigate some of its elements by comparison with dif...

journal_title：Japanese journal of ophthalmology

authors： Broekhuyse RM,Kuhlmann ED,Winkens HJ

更新日期：1996-01-01 00:00:00

abstract：:The clinical characteristics of 20 eyes of 20 consecutive patients with traumatic macular hole were studied retrospectively. The macular holes were elliptical with irregular edges in 19 eyes (95%) and ranged in size from 0.2 to 0.5 DD (disc diameter). Posterior vitreous detachment (PVD) was found in only 3 eyes (15%);...

journal_title：Japanese journal of ophthalmology

authors： Yanagiya N,Akiba J,Takahashi M,Shimizu A,Kakehashi A,Kado M,Hikichi T,Yoshida A

更新日期：1996-01-01 00:00:00

abstract：:Glycine is an important inhibitory neurotransmitter in the vertebrate retina. Although many reports of glycine localization by the immunocytochemical method have been published, none has distinguished the neurotransmitter function of glycine from metabolic change. If glycine is the neurotransmitter, it seems that it m...

journal_title：Japanese journal of ophthalmology

authors： Nishikawa S,Ishiguro S,Tamai M

更新日期：1996-01-01 00:00:00

abstract：:Fluoroquinolones provide an important single antibiotic therapy for bacterial keratitis caused by Staphylococcus aureus and numerous gram-negative bacteria, including Pseudomonas aeruginosa. The pharmacokinetics of three ocular fluoroquinolones, norfloxacin (CHIBOXIN, Merck, Sharp & Dohme), ciprofloxacin (CILOXAN, Alc...

journal_title：Japanese journal of ophthalmology

authors： Green LC,Callegan MC,Engel LS,Shimomura Y,Jasheway DW,O'Callaghan RJ,Hill JM

更新日期：1996-01-01 00:00:00

abstract：:Localization of carbonic anhydrase (CA) was investigated in the rat eye by light and electron microscopy, and the inhibitory effects on CA distribution in the rat eye were compared between dorzolamide and acetazolamide. The cobalt sulfide histochemical method was used to study the CA localization. Acidic osmification ...

journal_title：Japanese journal of ophthalmology

authors： Terashima H,Suzuki K,Kato K,Sugai N

更新日期：1996-01-01 00:00:00

abstract：:The effects of local hypothermia on postoperative inflammation, electroretinogram (ERG) and histological changes of the retina were evaluated in experimental vitrectomy in pressure-induced ischemic rabbit eyes. The solutions used for intraocular perfusion were maintained at 8 degrees C, 22 degrees C or 38 degrees C. F...

journal_title：Japanese journal of ophthalmology

authors： Tamai K,Toumoto E

更新日期：1996-01-01 00:00:00

abstract：:The usefulness of the Fluorotron Master fluorophotometer fitted with a small animal adapter was evaluated with tree shrews. We also determined that the optimal measurement parameters for these animals, which are regarded as promising for experimental use in ophthalmic research, are: fluorescein-Na concentration, 0.5 x...

journal_title：Japanese journal of ophthalmology

authors： Ishiko S,Yoshida A,Kitaya N,Abiko T,Mori F,Kado M,Takahashi M,Saito K

更新日期：1996-01-01 00:00:00

abstract：:The value of the polymerase chain reaction (PCR) in the diagnosis of stromal herpetic keratitis was examined using tear fluid specimens; the sensitivity of the nested PCR method in detecting the herpes simplex virus (HSV) genome was 1 plaque-forming unit/mL. PCR assay of 72 tear samples from the eyes of 15 patients wi...

journal_title：Japanese journal of ophthalmology

authors： Kudo E,Shiota H,Kinouchi Y,Mimura Y,Itakura M

更新日期：1996-01-01 00:00:00

abstract：:The glycocalyx, present on the surface of the corneal epithelium, contains sialoglycoconjugates. The developmental change in the sialylated residues may be evaluated by examining the expression of the sialyltransferase mRNA. We examined the distribution of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase mRNA in rat cor...

journal_title：Japanese journal of ophthalmology

authors： Uehara F,Ozawa M,Iwakiri N,Ohba N

更新日期：1995-01-01 00:00:00

abstract：:A surgically obtained lens from a 66-year-old man with the Weill-Marchesani syndrome was examined histopathologically by light microscopy, transmission electron microscopy and scanning electron microscopy. The lens was diffusely opaque and brown. It was microspherophakic in appearance, 6.0 mm in equatorial diameter an...

journal_title：Japanese journal of ophthalmology

authors： Nagata M,Takagi S,Yamasaki A,Tsunematsu S,Kumagami T,Itamochi C,Tamai A

更新日期：1995-01-01 00:00:00

abstract：:A unilateral intravitreal inoculation of herpes simplex virus type 1 (HSV-1) induced bilateral retinitis and encephalitis in the rat. Immunohistochemistry was employed to clarify the pathway of transmission of HSV-1 from the inoculated eye to the contralateral eye, and to identify localization of the viral antigen in ...

journal_title：Japanese journal of ophthalmology

authors： Matsushima M,Uyama M,Ohyama A,Ueyama T,Sugimoto T

更新日期：1995-01-01 00:00:00

abstract：:The motoneurons innervating the musculus levator palpebrae superioris (LPS) of the monkey, the cat and the rabbit were studied using horseradish peroxidase (HRP). Furthermore, LPS motoneurons of the cat and rabbit were studied by the double-labeling method using two fluorescent dyes as retrograde neuronal tracers. Aft...

journal_title：Japanese journal of ophthalmology

authors： Hiramoto D,Sekiya H,Kojima Y,Mukuno K,Ishikawa S

更新日期：1995-01-01 00:00:00

abstract：:Histochemical studies were carried out in the mouse on the changes and distribution patterns of glycosaminoglycan molecular species during the separation of the lens vesicle. To obtain embryos, pregnant mice of the Jcl:ICR strain were sacrificed on day 10.5 or 11 of pregnancy. Serial frontal sections were strained wit...

journal_title：Japanese journal of ophthalmology

authors： Mizuno S,Ikeda K,Hirabayashi Y

更新日期：1995-01-01 00:00:00

abstract：:A 25-year-old woman is described whose clinical features included infantile hypotonia, obesity after infancy, intellectual impairment, dysmorphic facial features, short stature, small hands and feet, and abnormal dentition, which are typical of the Prader-Willi syndrome. The patient had almond-shaped eyes, spot-like h...

journal_title：Japanese journal of ophthalmology

authors： Wang XC,Norose K,Kiyosawa K,Segawa K

更新日期：1995-01-01 00:00:00

abstract：:A 10-year-old girl complained or poor vision in both eyes. The patient showed progeria, physical and mental retardation, sensorineural hearing loss, cutaneous photosensitivity, hyperopia, poor pupillary dilation, exotropia, salt-and-pepper fundi, nondetectable cone and rod electroretinographic (ERG) responses, cerebra...

journal_title：Japanese journal of ophthalmology

authors： Ikeda N,Yamamoto S,Hayasaka S,Fukuo Y,Koike T

更新日期：1995-01-01 00:00:00

abstract：:A newly developed model of keratoepithelioplasty (KEP) in the rat was used to analyze the effect of anterior chamber-associated immune deviation on the suppression of corneal allograft rejection. The right eyes of Fisher rats received an anterior chamber (AC) injection of lymphocyte suspension from Dark Agouti (DA) ra...

journal_title：Japanese journal of ophthalmology

authors： Yao YF,Inoue Y,Hara Y,Kiritoshi A,Tano Y,Ohashi Y

更新日期：1994-01-01 00:00:00

abstract：:Dendritic keratitis occurred during oral acyclovir (ACV) therapy in a 60-year-old man. Corneal stromal edema and iritis were found at his first visit. Herpetic keratouveitis was suspected, based on clinical findings and previous history. Treatment with steroid eyedrops and ACV ointment was initiated. However, ACV [cor...

journal_title：Japanese journal of ophthalmology

authors： Mori Y,Inoue Y,Shimomura Y

更新日期：1994-01-01 00:00:00

abstract：:The superior colliculus (SC) plays an important role in the transformation of visual and auditory signals into motor commands to generate saccadic eye movements toward the targets. This study investigated the synaptic input patterns from the SC, into vertical eye movement-related superior and inferior rectus motoneuro...

journal_title：Japanese journal of ophthalmology

authors： Sasaki Y,Matsui H,Tamai A

更新日期：1994-01-01 00:00:00

abstract：:Photopic electroretinograms (ERGs) elicited with red or white flashes of various intensities under a bright background light were recorded in 119 eyes of 77 diabetic patients and 19 normal control eyes. The implicit time and amplitude of photopic ERGs were analyzed in relation to the stage of diabetic retinopathy, ie,...

journal_title：Japanese journal of ophthalmology

authors： Satoh S,Iijima H,Imai M,Abe K,Shibuya T

更新日期：1994-01-01 00:00:00

abstract：:A major and a minor ascorbate free radical (AFR) reductase were separated from the soluble fraction in the human lens cortex by DEAE-cellulose ion-exchange column chromatography. These AFR reductases also exhibited diaphorase activity using dichlorophenolindophenol and ferricyanide as electron acceptors. The major AFR...

journal_title：Japanese journal of ophthalmology

authors： Bando M,Obazawa H

更新日期：1994-01-01 00:00:00

abstract：:It is unknown whether aqueous flare is increased in eyes with prominent fundus lesions other than choroidal malignant melanoma. Therefore, we studied the aqueous flare in eyes with age-related macular degeneration (ARMD) using the laser flare-cell meter. Forty-three eyes of 27 patients with ARMD (age 67.0 +/- 14.0 yea...

journal_title：Japanese journal of ophthalmology

authors： Kubota T,Küchle M,Nguyen NX

更新日期：1994-01-01 00:00:00

abstract：:The proliferative activity of the lens epithelium in the early stages of cataract crisis was investigated in rats and mice using the 3H-thymidine autoradiographic method with the whole-mount preparations of total lens epithelial cells. Three-week-old Sprague-Dawley (SD) rats were given a diet which included galactose ...

journal_title：Japanese journal of ophthalmology

authors： Terubayashi H,Tsuji T,Okamoto S,Ikebe H,Akagi Y

更新日期：1993-01-01 00:00:00

abstract：:The spectral sensitivity of the ERG c-wave was studied in the chicken under yellow or red light adaptation of various intensities, ie, 1, 3, 4 and 5 W/m2 at the corneal surface in the former, and 3, 4 and 5 W/m2 in the latter. The peak wavelength of the spectral sensitivity curve of the c-wave amplitude under both yel...

journal_title：Japanese journal of ophthalmology

authors： Takahashi K,Fukuda A,Mori T,Takahashi Y,Onoe S,Yoshimura Y,Tazawa Y

更新日期：1993-01-01 00:00:00

abstract：:Four patients with asteroid hyalosis who complained of seeing multiple spherical floaters were examined. Except for multiple brilliant particles in the gelatinous vitreous, no abnormalities were found by ophthalmoscopic examination. Asteroid bodies usually cause no visual symptoms in most patients. Therefore it is unu...

journal_title：Japanese journal of ophthalmology

authors： Noda S,Hayasaka S,Setogawa T

更新日期：1993-01-01 00:00:00

abstract：:A nationwide, multicenter study of typical retinitis pigmentosa was carried out in collaboration with 13 university hospitals throughout Japan. A total of 253 patients, 122 males and 131 females, with a wide range of ages (mean 48 years), were registered during a two-month period in 1989. Determination of inheritance ...

journal_title：Japanese journal of ophthalmology

authors： Hayakawa M,Matsumura M,Ohba N,Matsui M,Fujiki K,Kanai A,Tamai M,Shiono T,Tokoro T,Akazawa Y

更新日期：1993-01-01 00:00:00

abstract：:Human lens epithelial cells (HLECs) with lens capsules were cultured to investigate the morphology and outgrowth potential of the cultured cells. Anterior lens capsules obtained during cataract surgery were placed cell side down in a medium in culture wells. Cultivation was successful with 24 of 36 specimens from seni...

journal_title：Japanese journal of ophthalmology

authors： Ibaraki N,Ohara K,Shimizu H

更新日期：1993-01-01 00:00:00

abstract：:Clinical, pathological and follow-up data on the 1,147 cases of retinoblastoma registered in Japan from 1975 to 1982 were statistically analyzed. The cumulative survival rate of the total 1,147 cases was 93.0% at 5 years and 90.3% at 10 years, calculated by the Kaplan-Meier method. The survival rate for the 757 unilat...

journal_title：Japanese journal of ophthalmology

authors：

更新日期：1992-01-01 00:00:00